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2.5 Data extraction Data extraction was independently performed by two reviewers (EP and ADR) in accordance with the PRISMA 2020 guidelines

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The yeast produces metabolites (monacolins) that are naturally-occurring HMG-CoA reductase inhibitors (one of these, monacolin K, is chemically identical to lovastatin)

In addition, future trials should avoid overly complex combinations of multiple interventions (e.g., including omega-3 s or protein) unless specifically designed to disentangle their effects

626,627,628 Experimental evidence is accumulating that astrocytes readily respond to lifestyle modifications, and may be instrumental in conferring clinical benefits

This shorter duration of action makes IGF-1 DES more suitable for research needing acute, localized effects or where rapid clearance is desired